Title : Stereospecific phosphorylation by the central mitotic kinase Cdk1-cyclin B.

Pub. Date : 2015 Apr 17

PMID : 25603287






1 Functional Relationships(s)
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1 We demonstrate that Cdk1-cyclin B, the central mitotic kinase, is specific for the trans conformation, not cis, of synthetic, locked Ser-Pro 11-residue peptide substrates, using LC-MSMS detection and sequencing of phosphorylated products. Proline cyclin dependent kinase 1 Homo sapiens