Title : β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1.

Pub. Date : 2015 Mar

PMID : 25598321






3 Functional Relationships(s)
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1 In this study, we showed that beta-elemene inhibits human non-small cell lung carcinoma (NSCLC) cell growth, and increased phosphorylation of ERK1/2, Akt and AMPKalpha. beta-elemene AKT serine/threonine kinase 1 Homo sapiens
2 Interestingly, metformin not only reversed the effect of beta-elemene on phosphorylation of Akt but also strengthened the beta-elemene-reduced DNMT1. beta-elemene AKT serine/threonine kinase 1 Homo sapiens
3 Metformin augments the effect of beta-elemene by blockade of Akt signalling and additively inhibition of DNMT1 protein expression. beta-elemene AKT serine/threonine kinase 1 Homo sapiens