Pub. Date : 2015 Mar
PMID : 25598321
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKalpha signalling pathways in human lung cancer cells: the role of Sp1. | beta-elemene | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | In this study, we showed that beta-elemene inhibits human non-small cell lung carcinoma (NSCLC) cell growth, and increased phosphorylation of ERK1/2, Akt and AMPKalpha. | beta-elemene | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | In addition, beta-elemene suppressed Sp1 protein expression, which was eliminated by either ERK1/2 or AMPK inhibitor. | beta-elemene | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Taken together, our results show that beta-elemene inhibits NSCLC cell growth via ERK1/2- and AMPKalpha-mediated inhibition of transcription factor Sp1, followed by reduction in DNMT1 protein expression. | beta-elemene | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | The reciprocal ERK1/2 and AMPKalpha signalling pathways contribute to the overall responses of beta-elemene. | beta-elemene | mitogen-activated protein kinase 3 | Homo sapiens |