Pub. Date : 2015 Apr
PMID : 25595329
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It has been recently suggested that the heme-catabolizing enzyme heme oxygenase-1 is an essential component of the mesenchymal stromal cell-driven immune suppressive response. | Heme | heme oxygenase 1 | Homo sapiens |
| 2 | Because mesenchymal stromal cells upregulate indoleamine 2,3-dioxygenase expression on interferon-gamma priming and indoleamine 2,3-dioxygenase requires heme as a cofactor for optimal catabolic function, we investigated the potential antagonism of heme oxygenase-1 activity on indoleamine 2, 3-dioxygenase and the impact on mesenchymal stromal cell immune plasticity. | Heme | heme oxygenase 1 | Homo sapiens |