Title : Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines.

Pub. Date : 2014 Fall

PMID : 25587329






2 Functional Relationships(s)
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1 While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 While celecoxib was able to block the 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated increase in COX-2 expression in MDA-MB-231 cells, it increased the expression of ABCG2 up to 4.27 times to the control level at mRNA level and with less intensity at protein level. Tetradecanoylphorbol Acetate mitochondrially encoded cytochrome c oxidase II Homo sapiens