Title : Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.

Pub. Date : 2014 Dec 30

PMID : 25587030






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Without affecting Akt phosphorylation, PMA increased phosphorylation of S6K (T389) and S6 (S240/244), and that was completely prevented by rapamycin. Tetradecanoylphorbol Acetate ribosomal protein S6 kinase B1 Homo sapiens
2 Yet, T421/S424 and S235/236 (p-S6K and p-S6, respectively) phosphorylation became rapamycin-insensitive in the presence of PMA. Tetradecanoylphorbol Acetate ribosomal protein S6 kinase B1 Homo sapiens