Title : Valproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.

Pub. Date : 2015 Apr

PMID : 25581256






1 Functional Relationships(s)
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1 We report, for the first time, that VPA activates a previously unrecognized calpain-dependent necroptosis cascade that initiates with JNK1 activation and involves AIF cleavage/nuclear translocation and H2AX phosphorylation as well as an altered Smac/DIABLO to XIAP balance. Valproic Acid mitogen-activated protein kinase 8 Homo sapiens