Pub. Date : 2015 Feb
PMID : 25580854
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We describe a small-molecule inhibitor of ABHD16A that depletes lyso-PSs from cells, including lymphoblasts derived from subjects with PHARC. | lysophosphatidylserine | abhydrolase domain containing 16A | Mus musculus |
| 2 | In mouse macrophages, disruption of ABHD12 and ABHD16A respectively increases and decreases both lyso-PSs and lipopolysaccharide-induced cytokine production. | lysophosphatidylserine | abhydrolase domain containing 16A | Mus musculus |
| 3 | Finally, Abhd16a(-/-) mice have decreased brain lyso-PSs, which runs counter to the elevation in lyso-PS in Abhd12(-/-) mice. | lysophosphatidylserine | abhydrolase domain containing 16A | Mus musculus |
| 4 | Finally, Abhd16a(-/-) mice have decreased brain lyso-PSs, which runs counter to the elevation in lyso-PS in Abhd12(-/-) mice. | lysophosphatidylserine | abhydrolase domain containing 16A | Mus musculus |
| 5 | Our findings illuminate an ABHD16A-ABHD12 axis that dynamically regulates lyso-PS metabolism in vivo, designating these enzymes as potential targets for treating neuroimmunological disorders. | lysophosphatidylserine | abhydrolase domain containing 16A | Mus musculus |