Title : Multiplex imaging and cellular target identification of kinase inhibitors via an affinity-based proteome profiling approach.

Pub. Date : 2015 Jan 12

PMID : 25579846






1 Functional Relationships(s)
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1 By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1). 1,2,3,4-tetrazine cyclin dependent kinase 1 Homo sapiens