Title : The double-edged sword of AMPK signaling in cancer and its therapeutic implications.

Pub. Date : 2015 Mar

PMID : 25575627






1 Functional Relationships(s)
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1 Importantly, recent studies showed that the anti-tumorigenic effects of many "indirect" AMPK activators such as anti-diabetic biguanides are not dependent on AMPK; rather the activation of AMPK induces the resistance to their cytotoxic effects, emphasizing the pro-tumorigenic effect of AMPK. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens