Title : Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis.

Pub. Date : 2015 Mar 6

PMID : 25575314






1 Functional Relationships(s)
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1 Although 1, 2 and pifithrin-alpha caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells. Reactive Oxygen Species tumor protein p53 Homo sapiens