Title : [Reversal effect and its mechanism of (- )-5-N-acetylardeemin on adriamycin resistance in multidrug-resistant cancer cells A549/Adr and MCF-7/Adr].

Pub. Date : 2014 Nov

PMID : 25571710






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The expressions of P-gp in MCF-7/Adr and A549/Adr cells were significantly inhibited by (- )-5-N-acetylardeemin. 5-N-acetylardeemin ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSION: (- )5-N-acetylardeemin could reverse the multidrug resistance in cancer cells through inhibiting the expression of P-gp and enhancing the intracellular accumulation of cytotoxic drug. 5-N-acetylardeemin ATP binding cassette subfamily B member 1 Homo sapiens