Pub. Date : 2015 Feb 4
PMID : 25569448
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockade of the Ras/Raf/ERK and Ras/PI3K/Akt Pathways by Monacolin K Reduces the Expression of GLO1 and Induces Apoptosis in U937 Cells. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Monacolin K could also reduce the Ras-dependent phosphorylation of ERK and Akt, and the subsequent translocation of nuclear factor kappa B (NF-kappaB) from cytosol to nucleus in U937 cells. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The underlying mechanisms of apoptotic activity of monacolin K were associated with inhibition of the Ras/Raf/ERK and Ras/PI3K/Akt signals and down-regulation of HMG-CoA reductase and glyoxalase 1. | Lovastatin | AKT serine/threonine kinase 1 | Homo sapiens |