Pub. Date : 2015 May
PMID : 25567426
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration. | Alcohols | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that colocalize in neurons from the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA). | Alcohols | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that colocalize in neurons from the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA). | Alcohols | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | A similarly delivered amplicon for scrambled siRNA did not inhibit TLR4 or MCP-1 expression nor reduce binge drinking, identifying a neuronal TLR4/MCP-1 signal that regulates the initiation of voluntary alcohol self-administration. | Alcohols | C-C motif chemokine ligand 2 | Homo sapiens |