Pub. Date : 2015
PMID : 25565400
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. | 10-decarbamoylmitomycin C | tumor protein p53 | Homo sapiens |
| 2 | Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction. | 10-decarbamoylmitomycin C | tumor protein p53 | Homo sapiens |
| 3 | We previously reported that the novel DMC induced beta-interstrand DNA crosslinks induce a p53-independent form of cell death. | 10-decarbamoylmitomycin C | tumor protein p53 | Homo sapiens |
| 4 | The p53-independent DMC cytotoxicity associates with the activation, and subsequent depletion, of Chk1. | 10-decarbamoylmitomycin C | tumor protein p53 | Homo sapiens |
| 5 | Our results suggest that DMC induces a p53-independent disassociation of ATR from chromatin that facilitates Chk1 checkpoint activation and Rad51 chromatin recruitment. | 10-decarbamoylmitomycin C | tumor protein p53 | Homo sapiens |