Pub. Date : 2015 Mar
PMID : 25563901
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The primary objective of this study was to investigate OATP1A2 transport activity using rosuvastatin as a probe substrate and evaluate competitive inhibition of its transport by beta-blockers. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1A2 | Homo sapiens |
| 2 | With the exception of carvedilol (IC50 of 3.2 microM), all of the other beta-blockers that were evaluated had a small or insignificant effect on OATP1A2-mediated uptake of rosuvastatin. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1A2 | Homo sapiens |
| 3 | On the other hand, tricyclic compounds with a short aliphatic amine chain inhibited OATP1A2-mediated rosuvastatin transport. | Rosuvastatin Calcium | solute carrier organic anion transporter family member 1A2 | Homo sapiens |