Title : Effects of rapamycin against paraquat-induced pulmonary fibrosis in mice.

Pub. Date : 2015 Jan

PMID : 25559956






2 Functional Relationships(s)
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1 Immunohistochemical staining and Western blotting showed that RAPA treatment significantly down-regulated the enhanced levels of TGF-beta1 and alpha-SMA in lung tissues caused by PQ exposure. Paraquat transforming growth factor, beta 1 Mus musculus
2 CONCLUSIONS: This study demonstrates that RAPA treatment effectively suppresses PQ-induced alveolar collapse and collagen deposition in lung tissues through reducing the expression of TGF-beta1 and alpha-SMA. Paraquat transforming growth factor, beta 1 Mus musculus