Title : Tumor necrosis factor-α promotes survival and phenotypic maturation of poly(I:C)-treated dendritic cells but impairs their Th1 and Th17 polarizing capability.

Pub. Date : 2015 May

PMID : 25559144






2 Functional Relationships(s)
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1 Tumor necrosis factor (TNF)-alpha may promote the survival of poly(I:C)-stimulated DCs, but it is not known in detail how this combination affects the maturation and polarization capacity of monocyte-derived (Mo)DCs. Poly I-C tumor necrosis factor Homo sapiens
2 However, TNF-alpha also decreased poly(I:C)-induced production of interleukin (IL)-12 and IL-23 by MoDCs, which correlated with their diminished capacity to stimulate cellular proliferation, interferon-gamma and IL-17 production by allogeneic CD4(+)T cells in co-culture. Poly I-C tumor necrosis factor Homo sapiens