Title : Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.

Pub. Date : 2015 Jan 1

PMID : 25556800






1 Functional Relationships(s)
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1 This plasticity results from a lack of steroid substrate as pre-treatment of mature thalamic slices (P20-24) with the GABAA R-inactive precursor 5alpha-dihydroprogesterone (5alpha-DHP) resulted in markedly prolonged mIPSCs and a greatly enhanced tonic conductance, mediated by synaptic and extrasynaptic GABAA Rs, respectively. 5-alpha-Dihydroprogesterone demilune cell and parotid protein 1 Mus musculus