Pub. Date : 2015 Feb
PMID : 25554447
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Correct metal insertion during SOD1 biosynthesis is critical to prevent misfolding; however Zn(2+) can bind to the copper-site leading to an aberrantly metallated protein. | Metals | superoxide dismutase 1 | Homo sapiens |
2 | Here we use complementary biophysical methods to investigate Zn(2+) binding and its effects on the aggregation of three immature metal-free SOD1 conformers that represent biogenesis intermediates: dimeric, monomeric and reduced monomeric SOD1. | Metals | superoxide dismutase 1 | Homo sapiens |