Title : Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation.

Pub. Date : 2015 Feb

PMID : 25554447






2 Functional Relationships(s)
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1 Correct metal insertion during SOD1 biosynthesis is critical to prevent misfolding; however Zn(2+) can bind to the copper-site leading to an aberrantly metallated protein. Metals superoxide dismutase 1 Homo sapiens
2 Here we use complementary biophysical methods to investigate Zn(2+) binding and its effects on the aggregation of three immature metal-free SOD1 conformers that represent biogenesis intermediates: dimeric, monomeric and reduced monomeric SOD1. Metals superoxide dismutase 1 Homo sapiens