Title : Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.

Pub. Date : 2015 Apr

PMID : 25548100






1 Functional Relationships(s)
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1 Concurrent Bcl-xL antagonism by the BH3 mimetic ABT-263 combined with carfilzomib synergistically enhanced apoptosis that was dependent on Bax or p53, and was attenuated by Noxa or Bik shRNA. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid tumor protein p53 Homo sapiens