Pub. Date : 2015 Mar 10
PMID : 25542807
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic responses to clopidogrel in 401 patients with acute coronary syndrome. | Clopidogrel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Notably, the carriers of ABCB1 C3435T were associated with lower levels of plasma clopidogrel and its active (clopi-H4) and inactive (CLPM) metabolites (all P<0.05 vs. non-carriers) which also correlated with subsequently decreased platelet inhibition (P<0.05 vs. non-carriers). | Clopidogrel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Meanwhile, ABCB1 C3435T plays an important role in intestinal absorption of clopidogrel which further affects the exposure to the active metabolite of clopidogrel and platelet aggregation. | Clopidogrel | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Meanwhile, ABCB1 C3435T plays an important role in intestinal absorption of clopidogrel which further affects the exposure to the active metabolite of clopidogrel and platelet aggregation. | Clopidogrel | ATP binding cassette subfamily B member 1 | Homo sapiens |