Title : Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling.

Pub. Date : 2015 Mar

PMID : 25542736






3 Functional Relationships(s)
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1 Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Alcohols myeloid differentiation primary response gene 88 Mus musculus
2 Alcohol induced significant LORR in wild-type mice; this was halved by MyD88 and TLR4 deficiency, and surprisingly nearly completely eliminated by TLR2 deficiency. Alcohols myeloid differentiation primary response gene 88 Mus musculus
3 In contrast, the interaction between morphine and alcohol was found to be MOR-, NF-kappaB-, TLR2- and MyD88-dependent, but did not involve TLR4 or Interleukin-1beta. Alcohols myeloid differentiation primary response gene 88 Mus musculus