Title : Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.

Pub. Date : 2015 Mar 28

PMID : 25542083






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, the most interesting observation was that both temozolomide and curcumin required ERK1/2 to induce autophagy. Curcumin mitogen-activated protein kinase 3 Homo sapiens
2 Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors. Curcumin mitogen-activated protein kinase 3 Homo sapiens
3 Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors. Curcumin mitogen-activated protein kinase 3 Homo sapiens