Title : Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells.

Pub. Date : 2015 Feb 1

PMID : 25541286






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFkappaB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells. shikonin nuclear factor kappa B subunit 1 Homo sapiens
2 In the presence of oxLDL (40 mug/ml), shikonin pretreatment reversed oxLDL-induced ROS production, antioxidant response element reporter activity, NFkappaB nuclear translocation, and intercellular adhesion molecule (ICAM)-1 and E-selectin expression and suppressed the increase of monocyte adhesion to endothelial cells. shikonin nuclear factor kappa B subunit 1 Homo sapiens
3 Taken together, these results suggest that shikonin protects against oxLDL-induced endothelial damage by suppressing ROS/NFkappaB-mediated ICAM-1 and E-selectin expression via up-regulation of PI3K/Akt/Nrf2-dependent antioxidant enzyme expression. shikonin nuclear factor kappa B subunit 1 Homo sapiens