Title : Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats.

Pub. Date : 2016 Mar

PMID : 25535091






3 Functional Relationships(s)
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1 Furthermore, PPT + LiCl treatment significantly increased ERalpha level in the nuclear fraction of hippocampus, and in the cytoplasmic fraction, the total level of GSK-3beta was declined after treatment with its increased phosphorylation at Ser-9 (inactivation form). Lithium Chloride glycogen synthase kinase 3 beta Rattus norvegicus
2 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride glycogen synthase kinase 3 beta Rattus norvegicus
3 This study suggested that PPT + LiCl treatment could inhibit the activation of cytoplasmic GSK-3beta and promote the nuclear translocation of ERalpha, and ERalpha together with GSK-3beta maybe the targets to preserve hippocampus-dependent cognitive ability after long-term ovariectomy. Lithium Chloride glycogen synthase kinase 3 beta Rattus norvegicus