Title : mTOR inhibition rescues osteopenia in mice with systemic sclerosis.

Pub. Date : 2015 Jan 12

PMID : 25534817






1 Functional Relationships(s)
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1 Collectively, this study identifies a previously unrecognized role of the FBN1/TGF-beta/IL4Ralpha/mTOR cascade in BMMSC lineage selection and provides experimental evidence that rapamycin treatment may provide an anabolic therapy for osteopenia in Fbn1(+/-) mice. Sirolimus transforming growth factor, beta 1 Mus musculus