Title : Mechanism of erythropoietin action on the erythroid progenitor cells induced from murine erythroleukemia cells (TSA8).

Pub. Date : 1989 Jan

PMID : 2553385






5 Functional Relationships(s)
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1 Stimulatory effects on erythropoietin response are observed with the addition of compounds affecting the cAMP level such as forskolin, phosphodiesterase inhibitor and cholera toxin only in the presence of erythropoietin. Cyclic AMP erythropoietin Mus musculus
2 Stimulatory effects on erythropoietin response are observed with the addition of compounds affecting the cAMP level such as forskolin, phosphodiesterase inhibitor and cholera toxin only in the presence of erythropoietin. Cyclic AMP erythropoietin Mus musculus
3 cAMP analogues themselves show no stimulatory effect on TSA8 cells, nor does erythropoietin increase cAMP level in the cells. Cyclic AMP erythropoietin Mus musculus
4 Thus, it is suggested that cAMP does not act as a direct second messenger for signal transduction through erythropoietin receptors, but as a stimulator of the erythropoietin receptor pathway and/or as a second messenger in combination with the receptor pathway. Cyclic AMP erythropoietin Mus musculus
5 Thus, it is suggested that cAMP does not act as a direct second messenger for signal transduction through erythropoietin receptors, but as a stimulator of the erythropoietin receptor pathway and/or as a second messenger in combination with the receptor pathway. Cyclic AMP erythropoietin Mus musculus