Pub. Date : 2015 Feb
PMID : 25533502
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Butein suppresses ICAM-1 expression through the inhibition of IkappaBalpha and c-Jun phosphorylation in TNF-alpha- and PMA-treated HUVECs. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Moreover, butein abolished TNF-alpha- and PMA-induced IkappaBalpha phosphorylation, which participates in NF-kappaB activation, and PMA-induced phosphorylation of c-Jun, a subunit composed of AP-1. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | In vitro, butein inhibited the phosphorylation of c-Jun, binding to GST beads, mediated by JNK isolated from PMA-treated cells. | Tetradecanoylphorbol Acetate | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |