Title : Zebrafish cardiotoxicity: the effects of CYP1A inhibition and AHR2 knockdown following exposure to weak aryl hydrocarbon receptor agonists.

Pub. Date : 2015 Jun

PMID : 25532870






2 Functional Relationships(s)
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1 Moderately strong AHR agonists, such as benzo[a]pyrene and beta-naphthoflavone, have been shown to cause similar cardiotoxic effects when coupled with a cytochrome P450 1A (CYP1A) inhibitor, such as fluoranthene (FL). Benzo(a)pyrene cytochrome P450, family 1, subfamily A Danio rerio
2 Moderately strong AHR agonists, such as benzo[a]pyrene and beta-naphthoflavone, have been shown to cause similar cardiotoxic effects when coupled with a cytochrome P450 1A (CYP1A) inhibitor, such as fluoranthene (FL). Benzo(a)pyrene cytochrome P450, family 1, subfamily A Danio rerio