Pub. Date : 2015 May
PMID : 25521189
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: Dexrazoxane exposure induced topoisomerase IIalpha (TOP2A)-dependent cell death, gamma-H2AX accumulation and increased tail moment in neutral comet assays. | Dexrazoxane | DNA topoisomerase II alpha | Homo sapiens |
| 2 | ATF3 protein was induced by dexrazoxane in a concentration- and time-dependent manner, which was abolished in TOP2A-depleted cells and in cells pre-incubated with ATM inhibitor. | Dexrazoxane | DNA topoisomerase II alpha | Homo sapiens |
| 3 | CONCLUSIONS AND IMPLICATIONS: As with other TOP2A poisons, dexrazoxane induced DNA double-strand breaks followed by activation of the DNA damage response. | Dexrazoxane | DNA topoisomerase II alpha | Homo sapiens |