Title : The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.

Pub. Date : 2015 May

PMID : 25521189






1 Functional Relationships(s)
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1 Dexrazoxane induced DNA damage responses, shown by enhanced levels of gamma-H2AX/53BP1 foci, ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3-related), Chk1 and Chk2 phosphorylation, and by p53 accumulation. Dexrazoxane checkpoint kinase 2 Homo sapiens