Pub. Date : 2015 Jan
PMID : 25520153
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | MATERIALS AND METHODS: Cell viability was measured by an MTT assay, while the expression of apoptotic markers, AKT, and survivin in response to sulindac and simvastatin was examined by Western blotting. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | CONCLUSION: Combined treatment with sulindac and simvastatin augmented their apoptotic potential in lung cancer cells through AKT signaling-dependent downregulation of survivin. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |