Title : Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.

Pub. Date : 2015 Jan 30

PMID : 25519912






4 Functional Relationships(s)
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1 In contrast, mGluR4 has in common with other group III mGluR that it is activated with higher potency and efficacy by L-SOP. Phosphoserine glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus
2 Enhanced versions of the evolutionary trace (ET) algorithm were used to identify residues that when swapped between mGluR1 and mGluR4 increased the potency of L-SOP inhibition relative to the potency of L-glutamate activation in mGluR1 mutants and others that diminished the potency/efficacy of L-SOP for mGluR4 mutants. Phosphoserine glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus
3 Enhanced versions of the evolutionary trace (ET) algorithm were used to identify residues that when swapped between mGluR1 and mGluR4 increased the potency of L-SOP inhibition relative to the potency of L-glutamate activation in mGluR1 mutants and others that diminished the potency/efficacy of L-SOP for mGluR4 mutants. Phosphoserine glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus
4 Enhanced versions of the evolutionary trace (ET) algorithm were used to identify residues that when swapped between mGluR1 and mGluR4 increased the potency of L-SOP inhibition relative to the potency of L-glutamate activation in mGluR1 mutants and others that diminished the potency/efficacy of L-SOP for mGluR4 mutants. Phosphoserine glutamate receptor, ionotropic, AMPA4 (alpha 4) Mus musculus