Title : Interactions of multitargeted kinase inhibitors and nucleoside drugs: Achilles heel of combination therapy?

Pub. Date : 2015 Jan

PMID : 25519698






1 Functional Relationships(s)
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1 In clinical settings, TKI inhibitor concentrations in tumor tissues are sufficient to inhibit hENT1 activity, thereby reducing nucleoside chemotherapy drug levels in cancer cells and reducing efficacy in combination schedules. Nucleosides solute carrier family 29 member 1 (Augustine blood group) Homo sapiens