Title : Expression of normal and translocated c-myc alleles in Burkitt's lymphoma cells: evidence for different regulation.

Pub. Date : 1989 Jul

PMID : 2551669






4 Functional Relationships(s)
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1 Expression of the translocated c-myc alleles was also affected by TPA; however, only if cycloheximide was simultaneously present. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 TPA plus cycloheximide induced a rapid decrease of c-myc RNA derived from the translocated allele within 6 h, whereas cycloheximide alone led to abolition of c-myc RNA after 16-24 h. This rapid decline of c-myc RNA was observed in Raji and BL41 cells, but not in three cell lines with variant t(2;8) and t(8;22) translocations. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens