Title : In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.

Pub. Date : 2015

PMID : 25515270






1 Functional Relationships(s)
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1 We report that treatment of human neutrophils with the delta-PKC inhibitor rottlerin significantly attenuates f-Met-Leu-Phe (fMLF)-induced MARCKS phosphorylation (IC50=5.709 muM), adhesion (IC50=8.4 muM), and migration (IC50=6.7 muM), while alpha-, beta-, and zeta-PKC inhibitors had no significant effect. rottlerin myristoylated alanine rich protein kinase C substrate Homo sapiens