Pub. Date : 2015 Jan 14
PMID : 25514511
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The principal pharmacological effects of aspirin are known to arise from its covalent modification of cyclooxygenase-2 (COX-2) through acetylation of Ser530, but the detailed mechanism of its biochemical action and specificity remains to be elucidated. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | The principal pharmacological effects of aspirin are known to arise from its covalent modification of cyclooxygenase-2 (COX-2) through acetylation of Ser530, but the detailed mechanism of its biochemical action and specificity remains to be elucidated. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | The computational results confirmed that aspirin would be 10-100 times more potent against COX-1 than against COX-2, and revealed that this inhibition specificity between the two COX isoforms can be attributed mainly to the difference in kinetics rate of the covalent inhibition reaction, not the aspirin-binding step. | Aspirin | prostaglandin-endoperoxide synthase 2 | Homo sapiens |