Pub. Date : 2014 Dec 15
PMID : 25512388
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 2 | Here, we report that FL118 activates tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 3 | Here, we report that FL118 activates tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 4 | FL118 inhibits p53 polyubiquitination and monoubiquitination by Mdm2-MdmX E3 complex in cells and in cell-free systems. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 5 | Coimmunoprecipitation revealed that FL118 slightly decreases Mdm2-p53 interactions and moderately increases Mdm2-MdmX interactions, suggesting a change of targeting specificity of Mdm2-MdmX E3 complex from p53 to MdmX, resulting in accelerated MdmX degradation. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 6 | Coimmunoprecipitation revealed that FL118 slightly decreases Mdm2-p53 interactions and moderately increases Mdm2-MdmX interactions, suggesting a change of targeting specificity of Mdm2-MdmX E3 complex from p53 to MdmX, resulting in accelerated MdmX degradation. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 7 | Activation of the p53 pathway by FL118 induces p53-dependent senescence in colorectal cancer cells. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 8 | Activation of the p53 pathway by FL118 induces p53-dependent senescence in colorectal cancer cells. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |
| 9 | However, in the absence of p53 or in the presence of MdmX overexpression, FL118 promotes p53-independent apoptosis. | 7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione | tumor protein p53 | Homo sapiens |