Pub. Date : 2015 Jun
PMID : 25511794
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine the impact of alcohol on the metabolism of specific probes for CES1 (oseltamivir) and CES2 (aspirin). | Alcohols | carboxylesterase 1 | Homo sapiens |
| 2 | METHODS: The effect of alcohol on CES1- and CES2-mediated probe drug hydrolysis was determined in vitro using recombinant human carboxylesterase. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 3 | RESULTS: Alcohol significantly inhibited oseltamivir hydrolysis by CES1 in vitro but did not affect aspirin metabolism by CES2. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 4 | CONCLUSIONS: Alcohol significantly inhibited the hydrolysis of oseltamivir by CES1 both in vitro and in humans, but did not affect the hydrolysis of aspirin to salicylic acid by CES2. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 5 | These results suggest that alcohol"s inhibition of CES1 could potentially result in clinically significant drug interactions with other CES1-substrate drugs, but it is unlikely to significantly affect CES2-substrate drug hydrolysis. | Alcohols | carboxylesterase 1 | Homo sapiens |
| 6 | These results suggest that alcohol"s inhibition of CES1 could potentially result in clinically significant drug interactions with other CES1-substrate drugs, but it is unlikely to significantly affect CES2-substrate drug hydrolysis. | Alcohols | carboxylesterase 1 | Homo sapiens |