Title : Effects of bombesin on human small cell lung cancer cells: evidence for a subset of bombesin non-responsive cell lines.

Pub. Date : 1989 Aug

PMID : 2550492






1 Functional Relationships(s)
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Protein Name
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1 While all three SCLC lines expressed messenger RNA encoding pro-gastrin releasing peptide (GRP), only the NCI-H345 cells expressed detectable membrane receptors for GRP and responded to nanomolar concentrations of bombesin as shown by 125I-GRP binding, total inositol phosphate accumulation, and increased clonal growth in soft agarose. Inositol Phosphates gastrin releasing peptide Homo sapiens