Title : Nicotinamide sensitizes human breast cancer cells to the cytotoxic effects of radiation and cisplatin.

Pub. Date : 2015 Feb

PMID : 25504347






1 Functional Relationships(s)
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1 The aim of this study was to analyze the effect of the PARP inhibitor nicotinamide (NAM) on breast cancer cells with different BRCA1 expression or function, such as BRCA1-deficient MDA-MB-436 cells, low expression BRCA1 MCF-7 cells, and the BRCA1 wild-type MDA-MB-231 cells, to demonstrate its effects as a chemo- or radiosensitizing agent. Niacinamide poly(ADP-ribose) polymerase 1 Homo sapiens