Pub. Date : 2014 Dec 11
PMID : 25500904
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity. | Azithromycin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Analysis of molecular signaling pathways revealed that exposure to AZM reduced the phosphorylation of the S6 ribosomal protein, a downstream target of mTOR. | Azithromycin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | In vitro kinase studies using recombinant mTOR showed that AZM inhibited mTOR activity. | Azithromycin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | In vitro kinase studies using recombinant mTOR showed that AZM inhibited mTOR activity. | Azithromycin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | We show for the first time that AZM and to a lesser extent CLM act as immunosuppressive agents on CD4(+) T-cells by inhibiting mTOR activity. | Azithromycin | mechanistic target of rapamycin kinase | Homo sapiens |