Title : Mutations of p53 and KRAS activate NF-κB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells.

Pub. Date : 2015 Feb 28

PMID : 25499080






1 Functional Relationships(s)
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1 Silencing of p53 or KRAS in A549 or H358 cells either enhanced or attenuated the resistance of cells to cisplatin and taxol through promotion or suppression of the NF-kappaB p65 nuclear translocation. Paclitaxel tumor protein p53 Homo sapiens