Title : Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer.

Pub. Date : 2015 Feb 28

PMID : 25497868






2 Functional Relationships(s)
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1 Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin. Curcumin mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts. Curcumin mitochondrially encoded cytochrome c oxidase II Homo sapiens