Title : Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

Pub. Date : 2015 Apr

PMID : 25496264






3 Functional Relationships(s)
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1 Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. gingerol UDP glucuronosyltransferase family 2 member B7 Homo sapiens
2 UGT1A8 (an intestinal enzyme), UGT1A9 and UGT2B7 were the enzymes showing the highest activity towards gingerols. gingerol UDP glucuronosyltransferase family 2 member B7 Homo sapiens
3 Further, activity correlation analyses indicated that UGT2B7 and UGT1A9 were primarily responsible for 4"-O-glucuronidation and 5-O-glucuronidation of gingerols in the liver, respectively. gingerol UDP glucuronosyltransferase family 2 member B7 Homo sapiens