Title : The effect of simvastatin and pravastatin on arterial blood pressure, baroreflex, vasoconstrictor, and hypertensive effects of angiotensin II in Sprague-Dawley rats.

Pub. Date : 2014 Dec

PMID : 25492829






4 Functional Relationships(s)
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1 Controls and simvastatin and pravastatin groups showed a significant increase in mean arterial BP and heart rate in response to Ang II. Simvastatin angiotensinogen Rattus norvegicus
2 In contrast, when pretreated with hexamethonium, a ganglionic blocker, simvastatin and pravastatin groups showed a similar hypertensive response to Ang II, which was smaller than in controls. Simvastatin angiotensinogen Rattus norvegicus
3 Likewise, the Ang II-induced vasoconstrictor response of femoral artery branches was comparable between simvastatin and pravastatin groups and smaller than in controls. Simvastatin angiotensinogen Rattus norvegicus
4 This study shows that simvastatin and pravastatin differ in their effects on the Ang II-dependent mechanisms controlling BP. Simvastatin angiotensinogen Rattus norvegicus