Pub. Date : 1989 Sep 15
PMID : 2549064
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutational replacements of specific residues in the GTP-binding pocket of the 21-kDa ras proteins (p21ras) reduce their GTPase activity. | Guanosine Triphosphate | Harvey rat sarcoma virus oncogene | Mus musculus |
| 2 | alpha s in which leucine replaces glutamine 227 (corresponding to glutamine 61 of p21ras) constitutively activates adenylyl cyclase and reduces the kcat for GTP hydrolysis more than 100-fold. | Guanosine Triphosphate | Harvey rat sarcoma virus oncogene | Mus musculus |
| 3 | We conclude that alpha s residues near glutamine 227 and glycine 49 participate in binding and hydrolysis of GTP, although the GTP binding regions of alpha s and p21ras are not identical. | Guanosine Triphosphate | Harvey rat sarcoma virus oncogene | Mus musculus |
| 4 | We conclude that alpha s residues near glutamine 227 and glycine 49 participate in binding and hydrolysis of GTP, although the GTP binding regions of alpha s and p21ras are not identical. | Guanosine Triphosphate | Harvey rat sarcoma virus oncogene | Mus musculus |