Pub. Date : 2014
PMID : 25490093
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53-dependent activation of microRNA-34a in response to etoposide-induced DNA damage in osteosarcoma cell lines not impaired by dominant negative p53 expression. | Etoposide | tumor protein p53 | Homo sapiens |
| 2 | In this study we evaluated the cascade of events determined by etoposide-induced DNA damage in OS cell lines with different p53 status focusing on methylation status and expression of miR-34a that modulate tumor cell growth and cell cycle progression. | Etoposide | tumor protein p53 | Homo sapiens |
| 3 | Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase. | Etoposide | tumor protein p53 | Homo sapiens |
| 4 | Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase. | Etoposide | tumor protein p53 | Homo sapiens |
| 5 | Wild-type p53 U2-OS cells and U2-OS cells expressing dominant-negative form of p53 (U2- OS175) were more sensitive to etoposide than p53-deficient MG63 and Saos-2 cells, showing increased levels of unmethylated miR-34a, reduced expression of CDK4 and cell cycle arrest in G1 phase. | Etoposide | tumor protein p53 | Homo sapiens |
| 6 | Consistently, in p53siRNA transfected U2-OS cells we observed loss of miR-34a induction after etoposide exposure associated with a partial gain of gene methylation and cell cycle progress towards G2/M phase. | Etoposide | tumor protein p53 | Homo sapiens |
| 7 | In conclusion, cell response to etoposide-induced DNA damage was not compromised in cells with dominant-negative p53 expression. | Etoposide | tumor protein p53 | Homo sapiens |