Pub. Date : 2015 Feb
PMID : 25489907
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The extensively polymorphic CYP2B6 gene metabolizes endogenous and exogenous compounds, among which are nicotine and bupropion, although its contribution to the systemic metabolism of nicotine still remains controversial. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The extensively polymorphic CYP2B6 gene metabolizes endogenous and exogenous compounds, among which are nicotine and bupropion, although its contribution to the systemic metabolism of nicotine still remains controversial. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | The reduced activity of the CYP2B6*6 variant was significantly (p=0.025) distributed among the nicotine-dependent individuals compared to non-nicotine dependents. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | The reduced activity of the CYP2B6*6 variant was significantly (p=0.025) distributed among the nicotine-dependent individuals compared to non-nicotine dependents. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | Also, the CYP2B6*1/*6 genotype achieved statistical significance (p=0.016) within the nicotine-dependent individuals. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | The high occurrence of CYP2B6*6 carriers among nicotine-dependent individuals may suggest a possible involvement in nicotine dependence, with a potential impact on smoking cessation treatments tailored to the individual smoker"s genotype. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | The high occurrence of CYP2B6*6 carriers among nicotine-dependent individuals may suggest a possible involvement in nicotine dependence, with a potential impact on smoking cessation treatments tailored to the individual smoker"s genotype. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |